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| 1: Cheating Death |
| May 11, 2018 |
| As Bill breaks down the science of aging, his correspondents try bizarre beauty treatments and learn how spinach could transform organ transplants. |
| 2: Surviving in a World Without Water |
| May 11, 2018 |
| Derek Muller discovers why Mexico City is sinking, Nazeem Hussain tests his desert survival skills, and Bill has a drink with a "water sommelier". |
| 3: The Addiction Episode |
| May 11, 2018 |
| Bill explains how addiction changes the brain, comedian Maria Bamford shares her struggles, and Cara Santa Maria visits a research lab casino. |
| 4: Recipes from the Future |
| May 11, 2018 |
| Karlie Kloss tours Japanese farms that grow produce without soil to save water and space. Back in the studio, Margaret Cho samples meat made in a lab. |
| 5: Evolution: The Fact of Life |
| May 11, 2018 |
| In London, mutated mosquitos make a meal of Derek Muller. Comedian Paul F. Tompkins helps Bill burst a common myth about evolution. |
| 6: What is Your Pet Really Thinking? |
| May 11, 2018 |
| Do dogs get depressed? Do monkeys like magic tricks? Bill and his guests explore animal behavior that's remarkably human |